Titlebook: Hematopoietic Stem Cells; Keystone of Tissue D Meng Zhao,Pengxu Qian Book 2023 The Editor(s) (if applicable) and The Author(s), under exclu

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Multi-lineage Differentiation from Hematopoietic Stem Cells,vely limits the self-renewal potential of the original HSCs by regulating the level of lineage-specific gene expression. In this review, we will summarize the current understanding of the molecular mechanisms underlying HSC differentiation toward erythroid, myeloid, and lymphocyte lineages. Moreover

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Gene Editing in Hematopoietic Stem Cells,nd powerful gene editing tools has provided researchers with great convenience in genetically modifying a wide range of cells, including hematopoietic stem and progenitor cells (HSPCs). In addition to being used to modify genes to study the functional role that specific genes play in the hematopoiet

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Aging, Causes, and Rejuvenation of Hematopoietic Stem Cells,lopment of aging-associated hematopoietic diseases and malignancies. In this section, we provide a summary of the key hallmarks associated with HSC aging. We also examine the causal factors that contribute to HSC aging and emphasize potential approaches to mitigate HSC aging and age-related hematopo

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Book 2023g, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation,

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Xiaoyuan Zeng,Yi-Ping Wang,Cheuk-Him Mane flexible DNA molecules were displayed as small bright spots continuously changing their shape due to Brownian motion. Recently, the radii of gyration, the persistence lengths, and diffusion constants of DNA complexes have been estimated from such images collected at different times [3,4].

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