| 書目名稱 | Hematopoietic Stem Cells | | 副標(biāo)題 | Keystone of Tissue D | | 編輯 | Meng Zhao,Pengxu Qian | | 視頻video | http://file.papertrans.cn/426/425573/425573.mp4 | | 概述 | Provides a comprehensive understanding of HSCs from embryonic development through adult maintenance to aging.Includes the research in epigenetics, metabolism and microenvironment and advanced technolo | | 叢書名稱 | Advances in Experimental Medicine and Biology | | 圖書封面 |  | | 描述 | .This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.. | | 出版日期 | Book 2023 | | 關(guān)鍵詞 | Hematopoietic stem cells; stem cell niche; epigenetics; metabolomics; aging; leukemic stem cells | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-99-7471-9 | | isbn_softcover | 978-981-99-7473-3 | | isbn_ebook | 978-981-99-7471-9Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor |
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