Titlebook: Handbook of Cancer Vaccines; Michael A. Morse,Timothy M. Clay,H. Kim Lyerly Book 2004 Springer Science+Business Media New York 2004 Antige

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Immune Defects in Cancerurnet and Lewis Thomas . has been recently highlighted in experiments with gene knockout mice. Compared with wild-type mice, mice lacking sensitivity to either interferon-γ (IFN-γ receptor-deficient mice) or all interferon (IFN) family members (i.e., Stat 1 -deficient mice) developed tumors more rap

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Immune Adjuvants need for effective delivery strategies and potent adjuvants to induce an appropriate immune response. Although there is evidence that many cancer patients do mount an immune response against their tumor, the affinity and frequency of responding T cells appears to be low. Additionally, the “natural”

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Peptide-Based Vaccinesnes. Improved understanding of the molecular basis of antigen recognition has resulted in the development of rationally designed tumor antigen—specific vaccines based on motifs predicted to bind to human class I or class II major histocompatibility complex (MHC) molecules. The use of synthetic pepti

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Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens the many tumorrestricted monoclonal antibodies derived by immunization of mice with human tumor cells, most have been directed against carbohydrate antigens expressed at the cell surface as glycolipids or mucins .. Antibodies against cell-surface antigens such as these are ideally suited for eradic

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Anti-Idiotype Vaccines a host antitumor response, in contrast to passive immunotherapy, where large doses of preformed antitumor antibodies, or T cells with predetermined specificity, are infused. In classical ASI, patients are vaccinated with purified tumor-specific or tumor-associated antigens (TAAs). This approach has

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Pox Viral Vaccineshich the presentation of these TAAs to the immune system results in far greater activation of T cells than is being achieved naturally in the host. One approach to create an inflammatory milieu designed to trigger a robust immune response to TAAs involves the use of recombinant viral vectors to deli