Titlebook: Handbook of Antimicrobial Resistance; Matthias Gotte (Editor-in-chief),Albert Berghuis,D Reference work 2017 Springer Science+Business Med

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https://doi.org/10.1057/9781403978264 features of RNA viral quasispecies such as internal interactions within mutant spectra and the effect of population size and bottleneck events as they affect the frequency of inhibitor-escape mutants. Genetic barriers to resistance and fitness cost of specific amino acid substitutions involved in r

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The European Context of the Wars,he selective pressure of therapy. Antiviral drug targets especially have a high mutational plasticity due to the diverse genetic viral population. An ideal antiviral inhibitor should be robust against these quasispecies. Fortunately, a therapeutic target can be evolutionarily constrained by the biol

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The Church and the Wars of the Roses, antibacterials is the β-lactams that target the transpeptidase enzymes, which are responsible for cross-linking the peptidoglycan cell wall. There are over 34 FDA-approved β-lactams which together constitute ~50 % of all antibiotic prescriptions worldwide (Tahlan K and Jensen SE, J Antibiot (Tokyo)