Titlebook: HIV Reservoirs; Methods and Protocol Guido Poli,Elisa Vicenzi,Fabio Romerio Book 2022 Springer Science+Business Media, LLC, part of Springe

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https://doi.org/10.1057/9780230348660t of therapeutic strategies to eradicate HIV. Primary cell models are based on the in vitro generation of latently infected cells using CD4T cells isolated from blood, lymph nodes or other lymphoid organs. In this chapter, we describe the generation of HIV latently infected memory CD4T cells using b

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https://doi.org/10.1057/9781137491510 a substantial resistance to the cytopathic effects triggered by viral infection. This feature, in addition to their homeostatic self-renewal capacity, strongly support the hypothesis that macrophages could serve as an additional reservoir of persistently infected cells in individuals receiving comb

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https://doi.org/10.1007/978-1-4020-5553-9cades, where it infects mainly microglial cells and astrocytes. Brain tissues from HIV-infected individuals have been shown to harbor HIV proviruses and to express early viral products with neurotoxic properties, like Tat. Egress of HIV from astrocytes to the periphery in animals further supports a

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