Titlebook: Glutamate and Neuropsychiatric Disorders; Current and Emerging Zoran M. Pavlovic Book 2022 Springer Nature Switzerland AG 2022 Aggression.A

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Current Glutamatergic Treatments and Future Directions for Glutamate-Based Management of Chronic St have been suggested to underlie the fast antidepressant properties of Ketamine. Alternative investigational therapeutic uses of Ketamine (besides as an antidepressant) will then be presented, followed by the description of other glutamatergic drugs which received significant attention for their pot

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The Role of the Glutamate System in Posttraumatic Stress Disorder and Glutamate-Based Treatments,ears a major shift in the conceptual framework of neuropsychiatric disorders has occurred, from the monoamine hypothesis to a neuroplasticity hypothesis, in which the glutamate system is conceived as a primary mediator of pathology and a straight target for antidepressant drugs. Novel potential trea

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Glutamate in Migraine Neurobiology and Treatment,ine to chronic migraine. Some of the current migraine treatments include in their mechanism of action, at least partly, modulation of glutamatergic signalling. While some attempts have been made to directly block glutamate receptors, these were abandoned due to the development of significant side ef

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Astrocyte Glutamate Transporter EAAT2 in Alzheimer Dementia,inical trials, synaptic glutamate signaling and EAAT2, I argue why EAAT2 drugs make therapeutic sense, and then describe a simple drug screening assay how to find them, by targeting the EAAT2 protein reconstituted in liposomes.