Titlebook: Gene Vaccines; Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer Book 2012 Springer-Verlag/Wien 2012 RNA and DNA vaccines.antigen-specific

樹(shù)木中

General Mechanisms of Gene Vaccines,is emerging. This introductory chapter will give a broad overview on the current status of gene vaccine design, their delivery and fate after introduction into the body, their immunostimulatory capacities, and finally, the processing and presentation of vaccine-encoded antigen to the immune system.

文藝

Strategies to Improve DNA Vaccine Potency: HPV-Associated Cervical Cancer as a Model System,tegies that modify the function of DCs. In this review, we use human papillomavirus (HPV)-associated cervical cancer as a model system to illustrate the various strategies that improve DNA vaccine potency. Specifically, we will discuss the various strategies to improve targeting of DNA to DCs, antig

平息

Immune-Activating Mechanisms of Replicase-Based DNA and RNA Vaccines and Their Role in Immune-Apopthe incorporation of gene sequences for the alphaviral replicase complex into a naked DNA plasmid. The original objective was to significantly increased antigen production with the help of a viral enzyme which replicates (vaccine encoded-) mRNA in transfected cells. Although this mechanism continues

MURAL

Corroborate

Improvement of DNA Vaccines by Electroporation,cently electroporation (EP) in particular, in combination with other technological developments such as species-specific codon optimization, improved RNA structural design, incorporation of novel leader sequences, novel formulations and adjuvant strategies have had a significant effect on immune out

Locale

,Electroporation Based TriGrid? Delivery System (TDS) for DNA Vaccine Administration,ite, rate, and timing of agent administration relative to the application of EP. This design ensures co-localization of the electrical fields with the site of genetic vaccine distribution and facilitates consistent procedure application independent of operator skill or experience. Device configurati

HIKE

adequate-intake

Intralymphatic Vaccination,y other infectious agents, the discussion and comparison of these different routes usually focuses on patient convenience, reduction of pain and distress for children, cost and on the possibility for mass vaccination. In this review, however, we would like to focus on how the route of administration

Meager

商店街

Current Status of Regulations for DNA Vaccines,view of the regulatory status and requirements for DNA vaccines intended for human use. We first introduce the regulatory process in Europe and in the USA and then highlight the most relevant aspects of the already existing guidance documents for DNA vaccines.