Titlebook: Gene Therapy for HIV; From Inception to a Gerhard Bauer,Joseph S. Anderson Book 2014 Gerhard Bauer and Joseph S. Anderson 2014 Anti-HIV ge

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https://doi.org/10.1007/978-3-662-11325-7shed by the insertion of naked DNA and the application of nonviral gene transfer (transfection) or viral gene transfer (transduction) methods. These methods vary widely in their gene transfer efficacy and also in the duration of expression of the transferred gene. For durable gene expression, retrov

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S?awomir Szymański,Piotr Bernatowiczhe first retroviral-mediated gene therapy clinical trials started in 1990, and the first stem cell gene therapy clinical trial (ADA deficiency), also retrovirally mediated, was initiated in 1994. The first stem cell gene therapy clinical trial for pediatric HIV was conducted in 1997, followed by a s

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Bulk-Edge Dualities in Topological Matter,uctive effects of HIV. Anti-HIV genes can be engineered to interfere with attachment, uncoating, reverse transcription, integration, expression, and budding of the virus. Target cells for HIV are CD4+ T cells, macrophages, monocytes, dendritic cells, and even brain microglia. All these cells are of

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The Simple Symmetric Random Walk, types of stem cells. They can be obtained either from the bone marrow or by mobilization and subsequent apheresis from the peripheral blood. After transplantation, there is no rejection issue; however, a high-enough transduction efficiency to elicit a clinical benefit is difficult to obtain. Select

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Classical and Spatial Stochastic Processesouse models were refined and could be applied for engraftment of human hematopoietic stem cells, generating a functional human immune system in these animals. Human immune cells generated in vivo could then be infected with HIV, and anti-HIV gene therapy applications could be tested in these mice. N

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Classical Capacities of Bosonic Channels,by several groups: T cell gene therapy and stem cell gene therapy clinical trials. Both have their unique advantages and disadvantages, with T cell gene therapy offering easier access to HIV target cells and greater transduction efficiencies, however, with the necessity to repeat the procedure to pr

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