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Titlebook: Gene Therapy for HIV; From Inception to a Gerhard Bauer,Joseph S. Anderson Book 2014 Gerhard Bauer and Joseph S. Anderson 2014 Anti-HIV ge

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發(fā)表于 2025-3-21 17:53:38 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱(chēng)Gene Therapy for HIV
副標(biāo)題From Inception to a
編輯Gerhard Bauer,Joseph S. Anderson
視頻videohttp://file.papertrans.cn/382/381978/381978.mp4
概述Contributors include scientists who developed the first clinical applications of stem-cell gene therapy for HIV.Outlines a path for a possible functional cure for HIV.Comprises a thorough and methodic
叢書(shū)名稱(chēng)SpringerBriefs in Biochemistry and Molecular Biology
圖書(shū)封面Titlebook: Gene Therapy for HIV; From Inception to a Gerhard Bauer,Joseph S. Anderson Book 2014 Gerhard Bauer and Joseph S. Anderson 2014 Anti-HIV ge
描述.This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV..Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients..In .Gene Therapy for HIV., Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In additi
出版日期Book 2014
關(guān)鍵詞Anti-HIV genes; CCR5 receptor knockout; Functional cure for HIV; Hematopoietic stem cells; Stem-cell gen
版次1
doihttps://doi.org/10.1007/978-1-4939-0434-1
isbn_softcover978-1-4939-0433-4
isbn_ebook978-1-4939-0434-1Series ISSN 2211-9353 Series E-ISSN 2211-9361
issn_series 2211-9353
copyrightGerhard Bauer and Joseph S. Anderson 2014
The information of publication is updating

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發(fā)表于 2025-3-21 22:09:57 | 只看該作者
Animal Models Used in HIV Gene Therapy,animals. Human immune cells generated in vivo could then be infected with HIV, and anti-HIV gene therapy applications could be tested in these mice. Nonhuman primates are also utilized for HIV research; however, the simian immunodeficiency virus (SIV) or a hybrid HIV–SIV needs to be applied for viral challenges.
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發(fā)表于 2025-3-22 01:57:02 | 只看該作者
2211-9353 le functional cure for HIV.Comprises a thorough and methodic.This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV..Gerhard Bauer applied ribozyme-anti-H
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Classical and Spatial Stochastic Processesanimals. Human immune cells generated in vivo could then be infected with HIV, and anti-HIV gene therapy applications could be tested in these mice. Nonhuman primates are also utilized for HIV research; however, the simian immunodeficiency virus (SIV) or a hybrid HIV–SIV needs to be applied for viral challenges.
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Tommaso Ruggeri,Masaru Sugiyamaon of multiple genes, with their active anti-HIV component being RNA or protein based. Safety features have been engineered into latest generation lentiviral vectors, and efficient vector production methods based on transient plasmid transfection methods have been developed.
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Exchange Modules and Exchange Rings,e can be expected. In the future, stem cells may also be generated from pluripotent stem cells, particularly induced pluripotent stem cells, promising large numbers of tested, HIV-resistant autologous stem cells for patients with HIV.
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