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Titlebook: Gene Therapy for Autoimmune and Inflammatory Diseases; Yuti Chernajovsky,Paul D. Robbins Book 2010 Birkh?user Basel 2010 Arthritis.Autoimm

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發(fā)表于 2025-3-21 19:16:06 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Gene Therapy for Autoimmune and Inflammatory Diseases
編輯Yuti Chernajovsky,Paul D. Robbins
視頻videohttp://file.papertrans.cn/382/381975/381975.mp4
叢書名稱Milestones in Drug Therapy
圖書封面Titlebook: Gene Therapy for Autoimmune and Inflammatory Diseases;  Yuti Chernajovsky,Paul D. Robbins Book 2010 Birkh?user Basel 2010 Arthritis.Autoimm
描述In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book pub
出版日期Book 2010
關(guān)鍵詞Arthritis; Autoimmune Diseases; DNA; Immunology; Inflammatory Diseases; Promoter; gene therapy; genes
版次1
doihttps://doi.org/10.1007/978-3-0346-0165-8
isbn_softcover978-3-0348-0306-9
isbn_ebook978-3-0346-0165-8Series ISSN 2296-6056 Series E-ISSN 2296-6064
issn_series 2296-6056
copyrightBirkh?user Basel 2010
The information of publication is updating

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Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy,ally, therapeutic targeting and exploitation of microRNAs. Application of this broad knowledge is being facilitated by the improvement of gene delivery vectors whose characteristics are being constantly improved and transformed to achieve tissue targeting, long-term expression, transcriptional control and low immunogenicity.
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https://doi.org/10.1007/978-3-211-69325-4s animal model, experimental autoimmune encephalomyelitis (EAE). Since progressive forms of MS remain orphan of efficient therapies, the field is open for less conventional interventions such as gene therapy.
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Introduction: Different Views of Psychologysues of arthritic joints, thereby redirecting their biology for sustained, local synthesis of therapeutic transgene products. A wide variety of transgenes and methods of delivery are currently under investigation for their capacity to block ongoing inflammation or stimulate repair and regeneration of cartilage tissues in OA.
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