Titlebook: Gadd45 Stress Sensor Genes; Dan A. Liebermann,Barbara Hoffman Book 20131st edition The Editor(s) (if applicable) and The Author(s), under

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Dan A. Liebermann,Barbara HoffmanProvides a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved.The functions of Gadd45 proteins are mediated by protein-protein inte

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David Siegel,Phillip Reigan,David Rossifferentiation cues. They are well-characterized regulators of cell cycle, senescence, survival, and apoptosis. More recently, it has become clear that Gadd45 proteins promote active DNA demethylation thereby mediating gene activation. This epigenetic function of Gadd45 is important for differentiat

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Giovana Rosso Cagnani,Gisela Ibá?ez-Redíndd45β, demonstrating due to a suppressive function that is often proapoptotic. This contrasts with normal hepatocytes, where Gadd45β facilitates cell survival, growth, and proliferation. Gadd45β binds MKK7—downstream of TNFα and its receptors—to prevent this kinase from activating JNK2. Hence, the .

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Giovana Rosso Cagnani,Gisela Ibá?ez-Redíndamage sensation and repair, genotoxic stress, neoplasia, and molecular epigenetics. The genes were originally identified in in vitro screens of irradiation- and interleukin-induced transcription and have since been implicated in a host of normal and aberrant central nervous system processes. These

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