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Titlebook: Gadd45 Stress Sensor Genes; Dan A. Liebermann,Barbara Hoffman Book 20131st edition The Editor(s) (if applicable) and The Author(s), under

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發(fā)表于 2025-3-21 17:50:27 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Gadd45 Stress Sensor Genes
編輯Dan A. Liebermann,Barbara Hoffman
視頻videohttp://file.papertrans.cn/381/380318/380318.mp4
概述Provides a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved.The functions of Gadd45 proteins are mediated by protein-protein inte
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Gadd45 Stress Sensor Genes; Dan A. Liebermann,Barbara Hoffman Book 20131st edition The Editor(s) (if applicable) and The Author(s), under
描述Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. ? The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).? These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.? Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. ? Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.? Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this boo
出版日期Book 20131st edition
關鍵詞gadd45 genes; gene function; proteins; stress sensors; stress signaling
版次1
doihttps://doi.org/10.1007/978-1-4614-8289-5
isbn_softcover978-1-4939-5390-5
isbn_ebook978-1-4614-8289-5Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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沙發(fā)
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David Siegel,Phillip Reigan,David Rossion and transcriptional regulation during development. Mechanistically, Gadd45 acts as an adapter for DNA repair factors at gene-specific loci to promote removal of 5-methylcytosine from DNA. Hence, Gadd45 is a nexus between DNA repair and epigenetic gene regulation.
地板
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Gadd45 Proteins: Key Players of Repair-Mediated DNA Demethylation,ion and transcriptional regulation during development. Mechanistically, Gadd45 acts as an adapter for DNA repair factors at gene-specific loci to promote removal of 5-methylcytosine from DNA. Hence, Gadd45 is a nexus between DNA repair and epigenetic gene regulation.
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發(fā)表于 2025-3-22 11:55:34 | 只看該作者
https://doi.org/10.1007/978-3-030-99662-8ng the production of circulating factors such as sFlt-1, which are believed to account for many of the pathophysiological-related symptoms of preeclampsia. Activation of inflammatory/immune responses in preeclampsia may function in a feedback loop to maintain elevated expression of Gadd45a protein.
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發(fā)表于 2025-3-22 16:20:34 | 只看該作者
Gadd45 Stress Sensors in Preeclampsia,ng the production of circulating factors such as sFlt-1, which are believed to account for many of the pathophysiological-related symptoms of preeclampsia. Activation of inflammatory/immune responses in preeclampsia may function in a feedback loop to maintain elevated expression of Gadd45a protein.
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978-1-4939-5390-5The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
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Gadd45 Stress Sensor Genes978-1-4614-8289-5Series ISSN 0065-2598 Series E-ISSN 2214-8019
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