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Titlebook: G Protein-Coupled Receptors in Drug Discovery; Methods and Protocol Marta Filizola Book 2015Latest edition Springer Science+Business Media

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書(shū)目名稱(chēng)G Protein-Coupled Receptors in Drug Discovery
副標(biāo)題Methods and Protocol
編輯Marta Filizola
視頻videohttp://file.papertrans.cn/381/380014/380014.mp4
概述Includes cutting-edge methods and protocols on GPCRs in drug discovery.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
叢書(shū)名稱(chēng)Methods in Molecular Biology
圖書(shū)封面Titlebook: G Protein-Coupled Receptors in Drug Discovery; Methods and Protocol Marta Filizola Book 2015Latest edition Springer Science+Business Media
描述.This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful .Methods in Molecular Biology. series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls..Practical and fully updated, .G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition. serves as an
出版日期Book 2015Latest edition
關(guān)鍵詞Allosteric modulators; Biased agonists; Drug design; Drug targets; GPCRs; Oligomer-selective ligands; Rece
版次2
doihttps://doi.org/10.1007/978-1-4939-2914-6
isbn_softcover978-1-4939-4967-0
isbn_ebook978-1-4939-2914-6Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media New York 2015
The information of publication is updating

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Design of Digital Campus Based on WebGISf the conformational landscape and are involved in activation. Through relaxation experiments spanning microseconds to seconds, lifetimes of these functional states can often be measured. By determining the effect of ligands on both equilibrium populations and rates of interconversion between states
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https://doi.org/10.1007/978-3-642-76764-7alculations. Several examples are discussed that illustrate specific steps that can be taken to improve upon the docking and virtual screening accuracy. While GPCRs are a unique target class, many of the methods and strategies outlined in this review are general and therefore applicable to other pro
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Cuddling and Spooning Other Menl, while other types of data are more useful at the stage of solution filtering. The protocol was successfully applied to modeling and design of a stable construct that resulted in crystallization of the first complex between a chemokine and its receptor. Examples from this work are used to illustra
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Purification of Stabilized GPCRs for Structural and Biophysical Analyses,tructural and biophysical studies. Example protocols for the purification of StaR proteins for analysis, ligand screening with the thiol-specific fluorochrome .-[4-(7-diethylamino-4-methyl-3-coumarinyl)phenyl]maleimide (CPM), surface plasmon resonance (SPR), and crystallization for structural studie
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