Titlebook: G Protein-Coupled Receptors in Drug Discovery; Methods and Protocol Marta Filizola Book 2015Latest edition Springer Science+Business Media

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Design of Digital Campus Based on WebGISf the conformational landscape and are involved in activation. Through relaxation experiments spanning microseconds to seconds, lifetimes of these functional states can often be measured. By determining the effect of ligands on both equilibrium populations and rates of interconversion between states

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https://doi.org/10.1007/978-3-642-76764-7alculations. Several examples are discussed that illustrate specific steps that can be taken to improve upon the docking and virtual screening accuracy. While GPCRs are a unique target class, many of the methods and strategies outlined in this review are general and therefore applicable to other pro

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Cuddling and Spooning Other Menl, while other types of data are more useful at the stage of solution filtering. The protocol was successfully applied to modeling and design of a stable construct that resulted in crystallization of the first complex between a chemokine and its receptor. Examples from this work are used to illustra

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Purification of Stabilized GPCRs for Structural and Biophysical Analyses,tructural and biophysical studies. Example protocols for the purification of StaR proteins for analysis, ligand screening with the thiol-specific fluorochrome .-[4-(7-diethylamino-4-methyl-3-coumarinyl)phenyl]maleimide (CPM), surface plasmon resonance (SPR), and crystallization for structural studie

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