Titlebook: eQTL Analysis; Methods and Protocol Xinghua Mindy Shi Book 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020 mining.g

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eQTL Mapping Using Transcription Factor Affinityction of eQTL that takes into account the combined effect of genetic variants within regulatory regions and leverages the idea that changes in gene expression often are the consequence of the alteration of transcription factor (TF) binding.

Biguanides

Identification and Quantification of Splicing Quantitative Trait Locing variation, which presumably affects gene regulation. In this chapter, we outline the recent progress made and methods used to discover putative regulatory regions associated with complex traits. We will specifically focus on mapping splicing quantitative trait loci (sQTL) using Yoruba samples from GEUVADIS as a motivating example.

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1064-3745 ation advice from the experts.This volume details state-of-art eQTL analysis, where interdisciplinary researchers are provided both theoretical and practical guidance to eQTL analysis and interpretation. Chapters guide readers through methods and tools for eQTL and QTL analysis and the usage of such

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https://doi.org/10.1007/978-3-319-43458-2genetic model to develop genome-wide composite interval mapping (GCIM). This chapter covers the GCIM procedure in a backcross or doubled haploid populations. We describe the genetic model, parameter estimation, multi-locus genetic model, hypothesis tests, and software. Finally, some issues related to the GCIM method are discussed.

明智的人

Modified Cyclodextrins for Chiral Separationmorigenesis and development. Here we describe a detailed workflow for identifying eQTLs in cancer using existing packages and software. The key package is Matrix eQTL, which requires input data of genotypes, genes expression, and covariates. This pipeline can be easily applied in a related research field.

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https://doi.org/10.1007/978-3-319-10070-8 their connections to various latent factors, i.e., latent interactions among genes and environmental factors. In this chapter, we introduce a new scheme to harmoniously integrate mean and high-order effects of genetic variants on expression quantitative trait. We rigorously evaluate its validity and utility of signal augmentation.

針葉

https://doi.org/10.1007/1-4020-3794-5ion. More and more researchers working on eQTL analysis realize the importance of other types of QTLs beyond eQTL. In this chapter, we will explore some QTLs beyond eQTLs that show the regulatory association with eQTLs and explain the underlying link among these types of QTLs.