Titlebook: Ewing Sarcoma; Methods and Protocol Florencia Cidre-Aranaz,Thomas G. P. Grünewald Book 2021 Springer Science+Business Media, LLC, part of S

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The Minerals, Metals & Materials Seriest to obtain the cell-of-origin of Ewing sarcoma that is tolerant of . expression. Here we describe the generation of the .-expressing mouse model for Ewing sarcoma by selecting embryonic chondrogenic progenitor, eSZ cells that contain Ewing sarcoma precursors.

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Raghavan Srinivasan,M. Ashraf Imamppropriate animal models for Ewing sarcoma, subcutaneous murine xenograft models currently offer the simplest way to investigate antineoplastic effects of therapeutics or biological functions of target genes in vivo. In order to properly carry out tumor growth analysis via subcutaneous xenografts of

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Germline Variation and Somatic Alterations in Ewing Sarcoma date, genetic investigations have identified key somatic mutations and germline variants of importance for EwS risk. While substantial progress is being made in uncovering the genetic etiology of EwS, considerable gaps in knowledge remain. Herein, we provide a summary of methodological approaches f

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Molecular Approaches to Diagnosis in Ewing Sarcoma: Fluorescence In Situ Hybridization (FISH)and molecular features. Though the implementation of broad RNA sequencing in diagnostic molecular pathology routines has substantially changed the standards of molecular affirmation of diagnoses, fluorescence in situ hybridization (FISH) on formalin-fixed, paraffin-embedded (FFPE) tissue sections is

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Molecular Approaches to Diagnosis in Ewing Sarcoma: RT-PCRations that give rise to fusion transcripts that codify for aberrant transcription factors. More than 95% of Ewing sarcoma harbor translocations that produce the fusion of the EWSR1 gene with the transcription factors FLI1 or ERG. This feature can be used to diagnose this entity unambiguously..In th

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Molecular Approaches to Diagnosis in Ewing Sarcoma: Targeted RNA Sequencinga variety of chimeric genes. Reference laboratories are increasingly implementing NGS-based techniques to overcome several limitations of conventional singleplex determinations. We have been early adopters of a targeted-RNA sequencing method based on Anchored multiplex PCR, which allows assessing se