Titlebook: Epigenetic Regulation of Lymphocyte Development; Cornelis Murre Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive

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Epigenetic Regulation of Lymphocyte Development978-3-642-24103-1Series ISSN 0070-217X Series E-ISSN 2196-9965

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0070-217X us differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.? .978-3-642-44767-9978-3-642-24103-1Series ISSN 0070-217X Series E-ISSN 2196-9965

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Alternatives Considered But Not Disclosedrangement of a .. gene segment to the DJ. junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.

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https://doi.org/10.1007/978-3-322-83467-6eceptor (pre-BCR), BCR and PI3K/Akt/mTOR signaling pathways is controlled by EBF1. In this review, we highlight these current developments and explore how EBF1 functions as a tissue-specific regulator of chromatin structure at B cell-specific genes.

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The Epigenetic Landscape of Lineage Choice: Lessons From the Heritability of , and , Expression,ty to manipulate these elements in the framework of development has added a new perspective on the temporal nature of their function and the epigenetic maintenance of gene expression. We examine herenovel insights into epigenetic mechanisms that have arisen through the study of these genes.

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Epigenetic Features that Regulate IgH Locus Recombination and Expression,rangement of a .. gene segment to the DJ. junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.

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Local and Global Epigenetic Regulation of V(D)J Recombination,c components that regulate V(D)J recombination of the immunoglobulin heavy chain locus in B cells, both in the context of the locus itself, and of its 3D nuclear organization, focusing in particular on non-coding RNA transcription. We will also speculate about how several newly described epigenetic mechanisms might impact on AgR regulation.