Titlebook: Epigenetic Regulation of Lymphocyte Development; Cornelis Murre Book 2012 The Editor(s) (if applicable) and The Author(s), under exclusive

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Epigenetic Features that Regulate IgH Locus Recombination and Expression, heavy chain (IgH) gene locus this is initiated by rearrangement of a .. gene segment to a .. gene segment to generate DJ. junctions, followed by rearrangement of a .. gene segment to the DJ. junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each

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Local and Global Epigenetic Regulation of V(D)J Recombination,and T cell receptor recombination is confined to T cells. This vital segregation of recombination targets is governed by the coordinated efforts of several epigenetic mechanisms that control both the general chromatin accessibility of these loci to the Rag recombinase, and the movement and synapsis

Externalize

Genetic and Epigenetic Regulation of , Gene Assembly,mic and finely tuned reprogramming of gene expression. The sophisticated orchestration of gene expression programs is driven primarily by changes in the patterns of covalent chromatin modifications. These epigenetic changes are directed by cis elements, positioned across the genome, which provide do

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T-Cell Identity and Epigenetic Memory,ession that is maintained while access to alternative hematopoietic lineages is permanently renounced. This combination of features could be explained by environmentally responsive transcription factor mobilization overlaying an epigenetically stabilized base gene expression state. For example, “poi

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Instinctive

The Epigenetic Landscape of Lineage Choice: Lessons From the Heritability of , and , Expression,e expression of the CD4 co-receptor on helper cells and the CD8 co-receptor on cytotoxic cells is intimately linked to this decision, and their regulation at the transcriptional level has been the subject of intense study to better understand lineage choice. Indeed, as the fate of developing T cells

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Wie “Alternativ” ist “Unbezahlte” Arbeit?ulatory elements and define a large fraction of the enhancer-like regions differentiated cell types. The formation of these regions of open chromatin enables the recruitment of secondary transcription factors that contribute additional transcription regulatory functionality required for the cell typ

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Forschung unter 500 Makler-Websites,ile system for elucidating relationships between the genetic and epigenetic components of gene regulation. This chapter describes our current understanding of the cross-talk between key genetic elements and epigenetic programs during recombination of the . locus in developing T cells, how each contr