Titlebook: Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery; Electrically Mediate Mark J. Jaroszeski,Richard Heller,Richard Gilb

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Electrochemotherapy, Electrogenetherapy, and Transdermal Drug DeliveryElectrically Mediate

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Numerical Modeling for In Vivo Electroporationisolated cells (.). Selected electric field intensity, appropriate for electroporation, should at the same time not exceed the value which will cause irreversible permeabilization or even death of the cell (.). This is particularly important for electro-gene transfection.

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The Basis of Electrochemotherapy drugs for which the plasma membrane is a barrier that limits their access inside the cell [termed nonpermeant drugs] (.). As illustrated in the various protocols reported in this volume, electrochemotherapy using bleomycin is efficient to eradicate subcutaneously transplanted and spontaneous small

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Treatment of Human Pancreatic Tumors Xenografted in Nude Mice by Chemotherapy Combined with Pulsed Ecan inhibit tumor growth in vivo in human pancreatic cancer xenografts. This was demonstrated in nude mice with BxPC-3 xenografts using fluorouracil, cisplatin, and doxorubicin with a consequent size reduction of the tumors between 72% and 79%, compared to the controls at day 28 after the first trea