| 書目名稱 | Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery | | 副標(biāo)題 | Electrically Mediate | | 編輯 | Mark J. Jaroszeski,Richard Heller,Richard Gilbert | | 視頻video | http://file.papertrans.cn/306/305920/305920.mp4 | | 概述 | Includes supplementary material: | | 叢書名稱 | Methods in Molecular Medicine | | 圖書封面 |  | | 描述 | Pulsed electric fields have been applied to living systems in vitro for a host of delivery applications since the early 1980s. It has been established that the primary effect that electrical treatment has on cells is an induced increase in the permeability of membranes to exogenous molecules. This state of increased permeability was noted to be temporary and could be induced with little or no effect on cell viability. This physical phenomenon was termed electroporation. Numerous published studies have shown that electroporation can be applied to any cell type. These studies also exploited the phenomenon to deliver drugs, DNA, antibodies, proteins, and fluorescent molecules. The use of electricity to mediate delivery of these molecule types in vitro has proven to be an invaluable research tool for biological and biomedical scientists. Many of the in vitro applications for electrically mediated delivery have tremendous potential for the treatment of human disease. For example, the ef- cient delivery of drugs and plasmid DNA has strong implications for improving standard therapies, as well as gene therapies. This potential was realized about 12 years ago when electric pulses were used | | 出版日期 | Book 2000 | | 版次 | 1 | | doi | https://doi.org/10.1385/1592590802 | | isbn_softcover | 978-1-61737-094-6 | | isbn_ebook | 978-1-59259-080-3Series ISSN 1543-1894 Series E-ISSN 1940-6037 | | issn_series | 1543-1894 | | copyright | Humana Press 2000 |
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