Titlebook: Effects of Nicotine on Biological Systems; Franz Adlkofer (Professor of Medicine, Scientific Book 1991 Springer Basel AG 1991 Alzheimer′s

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Ioannis Gkioulekas,Lazaros G. Papageorgiountitated in urine. Initial experiments found that about 50% of RIA reactive material could be removed by Extralut-3 chromatography which also retained a major portion of authentic trans 3′-hydroxycotinine added to non-smokers urine. This cotinine metabolite cross-reacted with 40% efficiency in the d

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,-n?chste Nachbarn und Ausrei?ererkennung,nstrated by the elimination parameters of .C-cotinine in isolated lung and liver. Phenobarbital (PB) induction markedly enhances the elimination of cotinine only in liver and not in lung..In conscious rats extrahepatic sites significantly contribute to the elimination of .C-nicotine. Hepatic first-p

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https://doi.org/10.1007/978-1-4302-6599-3t occur for standard cigarette types. The NNN and NNK burden of smokers is determined by the amount of the preformed nitrosamines NNN and NNK in tobacco and their transfer into the mainstream smoke. Thus the TSNA intake of smokers can be reduced by manufacturing cigarettes with low levels of preform

explicit

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Hazards in the Technical Environment,The exposure to carcinogenic nicotine-derived N-nitroso compounds from smokeless tobacco products is confined to preformed N-nitroso compounds (exogenous exposure) and not from the . nitrosation of nicotine . (endogenous exposure).

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