Titlebook: Drugs and the Developing Brain; Antonia Vernadakis (Associate Professor),Norman We Book 1974 Plenum Press, New York 1974 biology.brain.chi

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https://doi.org/10.1007/978-1-4757-2545-2rain enter and leave this organ. Many factors determine the concentration of drugs in the brain and it is the purpose of this paper to describe what these factors are and what changes occur during maturation. Thus, the volume of distribution of a drug, its pKa, the properties of the cerebral capilla

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Drugs and the Developing Brain978-1-4684-3063-9Series ISSN 0099-6246

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Development of Synaptic Substrates for Drug Actions in Immature Brainaptic substrate that constitutes the primary target of action of the pharmacological agent under investigation. Unfortunately this has rarely been possible for the obvious reason that there is a paucity of data available on the organization and properties of different subsystems during the developme

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dilute

Gonadal Hormones and the Developing Brain the fully mature brain. This age-dependent sensitivity of brain to hormones has been shown in studies of the ontogeny of gonadal function as well as in studies of the development of behavior. Research in these areas has been extensively reviewed in the past few years (Beach, 1971; Gorski, 1971; Goy

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Neurotransmitter Systems in the Central Nervous Systemion. Since interneuronal communication in mammalian systems involves chemical transmission, one might reason further that the ultimate purpose of central nervous system development is to develop mechanisms for the synthesis, storage and release of the substances which effect this interneuronal commu

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Studies on the Development of Tyrosine Hydroxylase, Monoamine Oxidase and Aromatic-L-Amino Acid Decarat brain by histochemical fluorescence procedures (Hillarp ., 1966; Ungerstedt, 1971). Norepinephrine neurons arise in the medulla oblongata and pons and either descend into the spinal cord to terminate in the ventral horn or ascend in the median forebrain bundle to terminate in the lower brain ste