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Titlebook: Drugs and the Developing Brain; Antonia Vernadakis (Associate Professor),Norman We Book 1974 Plenum Press, New York 1974 biology.brain.chi

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書目名稱Drugs and the Developing Brain
編輯Antonia Vernadakis (Associate Professor),Norman We
視頻videohttp://file.papertrans.cn/284/283209/283209.mp4
叢書名稱Advances in Behavioral Biology
圖書封面Titlebook: Drugs and the Developing Brain;  Antonia Vernadakis (Associate Professor),Norman We Book 1974 Plenum Press, New York 1974 biology.brain.chi
描述The thalidomide tragedy which occurred slightly more than a decade ago made public officials and the general public acutely aware of the teratogenic potential of drugs. Although specialists in pharmacology and developmental biology had been studying this problem many years before, this catastrophic episode triggered the passage of legislation which required that information about the teratogenicity of drugs be produced before the drugs could be available to the general public. Gross deformities in man produced by drugs are frequently difficult to reproduce in experimental animals and the changes which are produced in other animals are frequently not translatable to humans. The problem of evaluating the potential that drugs have to produce gross malformations is small, however, compared to the evaluation of subtle but permanent behavioral effects which drugs may exert upon the developing organism. Nevertheless, many experimental studies in recent years indicate that subtle biochemical changes produced by drugs on brain tissue during critical periods of fetal or early post- natal maturation may become manifest subsequently as behavioral deviations in early childhood or adolescence. H
出版日期Book 1974
關(guān)鍵詞biology; brain; childhood; development; developmental biology; drug; drugs; evaluation; pharmacology; researc
版次1
doihttps://doi.org/10.1007/978-1-4684-3063-9
isbn_softcover978-1-4684-3065-3
isbn_ebook978-1-4684-3063-9Series ISSN 0099-6246
issn_series 0099-6246
copyrightPlenum Press, New York 1974
The information of publication is updating

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Postnatal Behavioral Effects of , Exposure to Drugs which Modify Catecholamines and/or Serotoninn in various species, including man (Minkowski, 1922; Coghill, 1929; Windle, 1930; Kuo, 1932) through interactions between genetic and environmental factors (Thompson et al., 1962; Joffe, 1965) to an emphasis upon biochemical bases for genetic expression of control mechanisms in intermediary metabolism and transmitter function. (This symposium).
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R. G. Angus,R. A. Pigeau,R. J. Heslegraveon the postsynaptic membrane are among the most intensively studied subjects in neurobiology. Whereas considerable knowledge exists about the adult CNS, information concerning the differentiation of neurotransmisstion mechanisms during development has only recently begun to accumulate.
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The Phasing of Sleep in Animals innervate lower brain stem nuclei. Others either proceed laterally to terminate on the purkinje cells of the cerebellum, or ascend via the median forebrain bundle to terminate in such diverse regions as the hypothalamus, hippocampus, thalamus and cerebral cortex (Ungerstedt, 1971).
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Studies on the Development of Tyrosine Hydroxylase, Monoamine Oxidase and Aromatic-L-Amino Acid Deca innervate lower brain stem nuclei. Others either proceed laterally to terminate on the purkinje cells of the cerebellum, or ascend via the median forebrain bundle to terminate in such diverse regions as the hypothalamus, hippocampus, thalamus and cerebral cortex (Ungerstedt, 1971).
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