Titlebook: Drugs and a Methodological Compendium; From bench to bedsid Vikrant Singh Rajput,Ashish Runthala Book 2023 The Editor(s) (if applicable) an

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P,t in the drug development. Different methodologies have been applied in drug discovery time to time..Drug discovery has started with the usage of herbal extracts for different ailments, which were termed as traditional medicine. The knowledge, skills and practice of holistic health care, recognized

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Q,ates. These drugs are tested for pharmacological as well as toxicological evaluations to uncover their therapeutic applications for a particular disease. These tests followed by clinical trials allow studying the safety, efficacy and pharmacology of that molecule. These tests are conducted on a wide

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L,ion, preclinical evaluation, and finally human clinical trials. Once a new chemical entity (NCE) is discovered, it progresses toward the development process that includes preclinical and clinical pharmacology. Preclinical research includes in silico, in vitro, ex vivo, and in vivo studies using cell

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M,entry of novel drug molecules into the pharmaceutical market. This situation mandates the initiation of contemporary drug repurposing research strategies to reconnoiter the hidden off-label indications of de-risked compounds or existing approved drugs with established safety profile. This chapter le

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