Titlebook: Drugs and a Methodological Compendium; From bench to bedsid Vikrant Singh Rajput,Ashish Runthala Book 2023 The Editor(s) (if applicable) an

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macological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.978-981-19-7954-5978-981-19-7952-1

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O,l molecules usually utilized for drug discovery. Nevertheless, natural products retain unique features that differentiate them from conventional and outdated small-molecule drug leads, demanding novel techniques and access for evaluating their therapeutic capability. In this chapter, we scrutinize a

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Q,oxicokinetics using complex mathematical models. Despite significant breakthroughs in the field of in vitro test systems including 3D cell and organ culture techniques, the translational value of these systems is limited, and still mankind needs to traverse a long road ahead in this field. Undoubted

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L,dies that includes animal models and toxicology testing methodologies to identify a safe, potent, and efficacious drug. This chapter also highlights the importance of predictive and validated animal models for absorption, distribution, metabolism, and excretion (ADME) studies, along with the disease

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