Titlebook: Drug-Induced Liver Toxicity; Minjun Chen,Yvonne Will Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Acute li

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Introduction to the Windows Phone SDK,such an integrative predictor, we present four different classification schemes, i.e., an FDA labeling data-based approach (DILIrank dataset), a clinical evidence-based approach (LiverTox dataset), literature-based approaches (Greene and Xu datasets), and a registry-based approach (Suzuki dataset).

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E. Sally Rogers,Kim L. MacDonald-Wilsons to disrupt a biological process. Whereas the concentration of a drug in the liver is highly dependent on its physicochemical properties as these influence many pharmacokinetic characteristics. However, despite the ability to assess compounds for their potential to cause DILI using in silico method

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Anxiety Disorders and Work Performanceded to illustrate how the in vitro assays can help to derisk preclinical in vivo toxicity findings and to better predict clinical human liver toxicity outcomes. Opportunities in the DILI field are also discussed, in particular the need to use more relevant in vitro models to better mimic the in vivo

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Service Integration in Supported Employmentave contributed significantly to mechanistic studies of DILI, and various underlying signaling pathways and signatures of DILI have been identified. In this chapter, we first introduce the major hepatic lines (e.g., HepG2, Huh7, HepaRG, Hep3B, BC2, THLE, and Fa2N-4 cells), including their origins, c

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Danica Damljanovi?,Kalina Bontchevall-derived hepatocyte-like cells (PSC-HLCs) are a developing model which show promise for hepatotoxicity testing. However, the current phenotype of PSC-HLCs is closer to a fetal hepatocyte than an adult hepatocyte. The methodologies for generating mature PSC-HLCs close to an idealized hepatotoxicity

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Milan Stankovi?,Jelena Jovanovi?folds, and bioprinting enable precise control over the cellular microenvironment for enhancing and stabilizing hepatic functions in the presence of NPC types, including those derived from the liver towards determining their impact on DILI progression. The introduction of induced pluripotent stem cel

Detoxification