Titlebook: Drug Target miRNA; Methods and Protocol Marco F. Schmidt Book 2017 Springer Science+Business Media, LLC, part of Springer Nature 2017 drug

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Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Des (miRNA) mimicking compounds able to bind the miRNA-binding domain of Argonaute 2 protein (AGO2) to inhibit miRNA loading and its functional activity were described. Computer-aided molecular design techniques and RNA immunoprecipitation represent suitable approaches to identify and experimentally de

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Drug Target miRNA978-1-4939-6563-2Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Jan Feindt,Claudia Jan?en,Stefan S?lbrandtle oncogenic pathways and, therefore, provide a strong rationale for developing therapeutic miRNA mimics in combination with other therapeutic cancer agents to augment drug sensitivity. Here, we describe the experimental approach for evaluating miRNA and drug combinations using the “fixed ratio” method in cultured non-small cell lung cancer cells.

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Evaluating Synergistic Effects of miR-34a Mimics in Combination with Other Therapeutic Agents in Culle oncogenic pathways and, therefore, provide a strong rationale for developing therapeutic miRNA mimics in combination with other therapeutic cancer agents to augment drug sensitivity. Here, we describe the experimental approach for evaluating miRNA and drug combinations using the “fixed ratio” method in cultured non-small cell lung cancer cells.