Titlebook: Drug Resistance in Leishmania Parasites; Consequences, Molecu Alicia Ponte-Sucre,Emilia Diaz,Maritza Padrón-Niev Book 20131st edition Sprin

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Vaccines: Past, Present, and Futuresand fly saliva are evaluated as possible vaccine candidates in laboratories across the world, there has been no success in the clinic. The quest for an effective vaccine candidate continues. Progress in understanding . pathogenesis and host immunity coupled with the completion of . genome sequence

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American Tegumentary Leishmaniasisprognosis, and for control of the disease. The present chapter offers a description of American tegumentary leishmaniasis, a fundamental piece of knowledge for the comprehension of the challenges we face for leishmaniasis in times of drug resistance. As a way to better understand the unique scenario

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The Role of ABC Transporters in Drug-Resistant ,ociation of these proteins with drug resistance in leishmaniasis and its fundamental role in the pathology and pharmacology of this medically important protozoan parasite that currently infects around 12 million people in the world.

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Intracellular Mechanisms of Resistanceantioxidant pathways, e.g., nonprotein thiols, protects parasites from antimony-mediated oxidative stress. Indeed, in antimony-resistant strains, the increased biosynthesis of trypanothione (a bis(glutathionyl)spermidine conjugate, T[SH]2), the major intracellular thiol of . parasites, occurs, follo

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and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.978-3-7091-1125-3

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https://doi.org/10.1007/978-3-658-29715-2systems is being discussed. The final section highlights novel vaccination strategies based on the unique immunostimulatory and immunoregulatory functions of dendritic cells and considers future prospects of in situ targeting of dendritic cells.

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