Titlebook: Drug Discovery in Africa; Impacts of Genomics, Kelly Chibale,Mike Davies-Coleman,Collen Masimirem Book 2012 Springer-Verlag Berlin Heidelbe

符合規(guī)定

Marine Bioprospecting in Southern Africa,esiding off the more accessible southern African coast. A total of 18 South African marine natural products have been patented for their anti-cancer activity with the marine tube worm metabolite cephalostatin 1 and a synthetic analogue of the sponge metabolite hemiasterlin, showing the greatest promise for new drug development.

MUT

Natural Product-Based Drug Discovery in Africa: The Need for Integration into Modern Drug Discovery require a complete reevaluation of how natural product drug discovery is conducted on the continent, and in this chapter, we describe some of the components that could underpin this proposed transformation.

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Book 2012and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of m

RADE

fallible

Apostolos P. Fournaris,Daniel M. Heinwe examine (1) how the toxicity of anticancers is just a matter of dose or “only dose makes the poison,” as coined in Paracelsus’ Law; (2) and the potential of the anticancer methotrexate to treat malaria, thus demonstrating that the opportunity exists to discover new antimalarials using the anticancer pharmacopoeia.

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NIB

帶來

inhumane

Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stres that allow HSP to be selectively targeted. In this chapter, we review the international status of this area of research and highlight progress by us and other African researchers towards the characterisation and targeting of HSP from humans and parasites from . and . as drug targets.

cumulative

Anticancer Drug Repositioning Against Tropical Diseases: The Example of Methotrexate in the Treatmewe examine (1) how the toxicity of anticancers is just a matter of dose or “only dose makes the poison,” as coined in Paracelsus’ Law; (2) and the potential of the anticancer methotrexate to treat malaria, thus demonstrating that the opportunity exists to discover new antimalarials using the anticancer pharmacopoeia.