Titlebook: Drug Development in Psychiatry; Matthew Macaluso,Sheldon H. Preskorn,Richard C. Sh Book 2023 The Editor(s) (if applicable) and The Author(

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Reverse Engineering Drugs: Lorcaserin as an Example,

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Drug Development in Psychiatry: The Long and Winding Road from Chance Discovery to Rational Develophanism of action: blockade of the glutamate NMDA receptor. These studies coupled with earlier studies with other NMDA drugs suggest approximately 60% of patient with TRD are rapidly and robustly responsive to this mechanism of action. Thus, there appears to be three forms of MD based on pharmacologi

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Discovery and Development of Monoamine Transporter Ligands, result in their behavioral effects. This review focusses on recent examples of ligand-based structure-activity relationship studies trying to overcome some of the challenges associated with previously developed MAT inhibitors. These studies have led to the discovery of unique and novel structurally

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