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Titlebook: Drug Development in Psychiatry; Matthew Macaluso,Sheldon H. Preskorn,Richard C. Sh Book 2023 The Editor(s) (if applicable) and The Author(

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發(fā)表于 2025-3-21 17:50:42 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Drug Development in Psychiatry
編輯Matthew Macaluso,Sheldon H. Preskorn,Richard C. Sh
視頻videohttp://file.papertrans.cn/284/283063/283063.mp4
概述Reviews critical elements of both basic and clinical science as they pertain to drug development in psychiatry.It covers both historical elements and modern interpretations to understand best practice
叢書名稱Advances in Neurobiology
圖書封面Titlebook: Drug Development in Psychiatry; Matthew Macaluso,Sheldon H. Preskorn,Richard C. Sh Book 2023 The Editor(s) (if applicable) and The Author(
描述.The book reviews clinical trial methodology as it pertains to drug development in psychiatry. The reader will understand the process of drug development in psychiatry from discovery through marketing with the help of clinically relevant examples. The reader will appreciate the history of drug development in psychiatry dating back to the era of serendipitous discovery and culminating in an era of new and highly focused targets. Readers will understand how drug development in psychiatry has changed and adapted with the discovery of novel mechanism of action drugs. Novel drugs and disease targets have changed the way developers and regulatory agencies think about clinical trial methodology..The book elucidates how biomarkers, genetics and advances in neuroscience and neuroimaging have influenced drug development approaches, which will ultimately change the practice of psychiatry. The book will be broken down into the following sections:.a.?????? ?Prior to the 1960s - Drug discovery by chance observation.b.?????? The last 50 years – refined targeting of CNS drugs without the discovery of mechanistically new drugs.c.?????? The future – the discovery and development of mechanistically n
出版日期Book 2023
關(guān)鍵詞clinical trial; SPECT; APOE4; fMRI; florbetapir; biomarkers; clinical psychiatry; psychiatric medications
版次1
doihttps://doi.org/10.1007/978-3-031-21054-9
isbn_softcover978-3-031-21056-3
isbn_ebook978-3-031-21054-9Series ISSN 2190-5215 Series E-ISSN 2190-5223
issn_series 2190-5215
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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https://doi.org/10.1007/978-3-663-11765-0velopment, it is important to first understand the history of psychiatry including early attempts at drug discovery and develoment. The early history of psychiatry is mired with the use of inhumane experimental treatments and the institutionalization of patients in asylums. Some of the earliest drug
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Integrationstheorie und Mehrebenenpolitik,al models have been essential in the in vivo validation of novel drug targets, establishment of lead compound pharmacokinetic to pharmacodynamic relationships, optimization of lead compounds through preclinical candidate selection, and development of translational measures of target occupancy and fu
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Grundkonzepte der Programmierung and neurodegenerative disorders such as depression, ADHD, neuropathic pain, anxiety disorders, stimulant use disorders, epilepsy, and Parkinson’s disease. The MAT family is comprised of three main members – the dopamine transporter (DAT), the norepinephrine transporter (NET), and the serotonin tran
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Grundkonzepte der Programmierunghic and comorbid clinical characteristics. Is this medicine more effective, safe, tolerable, or affordable than the options used in the past? A payer may ask if the new medication offers a more effective, cost-efficient, or convenient alternative to those treatments already being covered. These are
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Objektorientierte Programmierungrom investments diverted to other therapeutic areas to reduced reliance on efficacy claims derived from preclinical models. In this chapter, we argue that there are several existing examples that teach us on what needs to be done to improve the success rate. We advocate the reverse engineering appro
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