Titlebook: Development and Engineering of Dopamine Neurons; R. Jeroen Pasterkamp,Marten P. Smidt,J. Peter H. B Book 2009 The Editor(s) (if applicable

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Book 2009tudies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has

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https://doi.org/10.1007/978-3-663-04510-6oughout adult life from neural stem cells in the subventricular zone of the lateral ventricle and rostral migratory stream. Adult born OB DA neurons are capable of integrating into existing circuits and do not appear to degenerate in Parkinson’s disease. Several genes have been identified that regul

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https://doi.org/10.1007/978-90-313-6319-3ysfunction. Due to this rather selective loss of DA neurons in the substantia nigra, PD is considered a neurological disease amenable to cell replacement. Cell replacement therapy in PD has been attempted in several hundred patients worldwide using fetal human DA neurons. While promising results hav

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Development of the Dopamine Systems in Zebrafish,oups in vertebrates. Here, we present an overview of the formation of dopaminergic groups and their projections in zebrafish. We will further review the results from genetic analyses, which have revealed insights on signals as well as transcription factors contributing to dopaminergic differentiatio

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Dopamine Systems in the Forebrain,oughout adult life from neural stem cells in the subventricular zone of the lateral ventricle and rostral migratory stream. Adult born OB DA neurons are capable of integrating into existing circuits and do not appear to degenerate in Parkinson’s disease. Several genes have been identified that regul

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Axon Guidance in the Dopamine System,erative disorders. Here we summarize our current knowledge of the ontogeny of mdDA axon projections in subsystems of the developing rodent central nervous system (CNS) and discuss the cellular and molecular mechanisms that mediate mdDA axon guidance in these CNS regions.