Titlebook: Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy; Emmanuel Donnadieu Book 2016 Springer International Publishing Switz

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Duane R. Hospenthal,Thomas J. Walshies. It is now recognized that not only the density, but also the organization of tumor-infiltrating immune cells is critical for the shaping of the tumor microenvironment. In human cancers, several levels of structuration of lymphoid aggregates have been observed, including Tertiary Lymphoid Struct

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Russell E. Lewis,Nathan P. Wiederholds in leukemia using CAR-modified T cells and in metastatic melanoma using tumor-infiltrating lymphocytes have provided impetus to expand adoptive cellular immunotherapy into treatment of solid tumors. In this setting, adoptively-transferred T cells face a hostile tumor environment that suppresses th

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Luis Ostrosky-Zeichner,Jack D. Sobellogical conditions. Yet they are also expressed in tumors and their metastases. There, they mediate a variety of tumor-specific functions, including the recruitment of different immune cell populations to the tumor site. These cells may have a pro- or anti-tumoral function. Yet the cells mediating t

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Basic Rules of T Cell Migration,enhancing antitumor responses, have kindled a huge interest in cancer immunotherapy. In fact, adoptive cell therapy (ACT) of tumor-recognizing T cells has led to complete recession of tumors in a subset of melanoma patients. Yet, the molecular mechanisms that guide T cells to infiltrate tumor tissue

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Regulation of Anti-tumor T Cell Migration and Function: Contribution of Real-Time Imaging,nt a major cell type in the antitumor immune response as they can specifically recognize and target transformed cells. Immunotherapies based on enhancing antitumor T cell functions are being actively developed with many clinical trials underway. Yet, the definition of basic migratory patterns of lym

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Vascular Normalization, T Cell Trafficking and Anti-tumor Immunity,eted immunotherapies. Treatments, such as cancer vaccines, CAR T cells and immune checkpoint inhibitors, aim to activate and harness T cells against cancer. However, tumors induce pathological angiogenesis and, at the same time, condition the tumor blood vessels to form a tumor vascular network that

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Disruption of Anti-tumor T Cell Responses by Cancer-Associated Fibroblasts,t the only component of a tumor and the non-cancer cell part of the tumor has been termed stroma. The tumor stroma comprises cells of at least three different origins: endothelial, mesenchymal and hematopoietic, thereby forming a complex microenvironment. Among these three elements, immune cells hav

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Cancer-Associated Tertiary Lymphoid Structures, from Basic Knowledge Toward Therapeutic Target in Cies. It is now recognized that not only the density, but also the organization of tumor-infiltrating immune cells is critical for the shaping of the tumor microenvironment. In human cancers, several levels of structuration of lymphoid aggregates have been observed, including Tertiary Lymphoid Struct

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Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy,s in leukemia using CAR-modified T cells and in metastatic melanoma using tumor-infiltrating lymphocytes have provided impetus to expand adoptive cellular immunotherapy into treatment of solid tumors. In this setting, adoptively-transferred T cells face a hostile tumor environment that suppresses th