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Titlebook: Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy; Emmanuel Donnadieu Book 2016 Springer International Publishing Switz

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發(fā)表于 2025-3-21 18:23:41 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
編輯Emmanuel Donnadieu
視頻videohttp://file.papertrans.cn/265/264734/264734.mp4
概述Gives the latest research on specific defects in T cell trafficking, which hinder the success of cancer immunotherapy.Provides the basic priniciples to T cell migration during efficient immune respons
叢書名稱Resistance to Targeted Anti-Cancer Therapeutics
圖書封面Titlebook: Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy;  Emmanuel Donnadieu Book 2016 Springer International Publishing Switz
描述This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers.?However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy..
出版日期Book 2016
關(guān)鍵詞Cancer Treatment; Anti-tumor immune response; Immogenic tumors; Cancer-associated fibroblasts; Cancer-as
版次1
doihttps://doi.org/10.1007/978-3-319-42223-7
isbn_softcover978-3-319-82528-1
isbn_ebook978-3-319-42223-7Series ISSN 2196-5501 Series E-ISSN 2196-551X
issn_series 2196-5501
copyrightSpringer International Publishing Switzerland 2016
The information of publication is updating

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Vascular Normalization, T Cell Trafficking and Anti-tumor Immunity, at the tumor blood vessel interface and how therapies that are effective in normalizing the tumor vasculature such as anti-VEGF, tyrosine kinase inhibitors and vaccines targeting tumor blood vessel-associated antigens, among others, can re-establish T cell infiltration into an inflammatory tumor mi
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Disruption of Anti-tumor T Cell Responses by Cancer-Associated Fibroblasts,espite their crucial role. Indeed, CAFs have been recently shown to be one of the more potent immune-suppressive cells of the tumor micro-environment. This chapter focuses on their roles on immune components of the tumor micro-environment, especially T cells. CAFs can impact T cells in two major way
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