Titlebook: Cytokine Knockouts; Scott K. Durum,Kathrin Muegge Book 19981st edition Springer Science+Business Media New York 1998 Colon.Vivo.cytokine.c

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IL-6 Gene Knockout Mice,, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) display overlapping activities with IL-6 that may be explained by a common receptor signal transducing component (gp 130). In order to clarify the unique functions of IL-6 in vivo, we have disrupted the murine IL-6 gene in the second exon b

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Myocardial, Hematological, and Placental Disorders Caused by Targeted Disruption of gp130, A Commone receptor complexes for IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1) .. The discovery of this shared signal transducer, gp 130, helps to explain how these different cytokines can mediate overlapping biological functions

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,Phenotypes of TGF? Knockout Mice, amino acid precursor. It has the characteristics of a secretory polypeptide, contains a hydrophobic signal sequence for translocation across the endoplasmic reticulum, and is glycosylated. The precursor cleavage site is a sequence of four basic amino acids immediately preceding the bioactive domain

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Contemporary Immunologyhttp://image.papertrans.cn/d/image/242629.jpg

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https://doi.org/10.1057/9781137513441 IL-1Ra is a specific receptor antagonist. IL-1α and IL-1β are synthesized as precursor molecules, without leader sequences. The molecular weight of each precursor is 31 kDa. Processing of IL-1α or IL-1β to “mature” forms of 17 kDa requires specific cellular proteases.