找回密碼
 To register

QQ登錄

只需一步,快速開始

掃一掃,訪問微社區(qū)

打印 上一主題 下一主題

Titlebook: Cytokine Knockouts; Scott K. Durum,Kathrin Muegge Book 19981st edition Springer Science+Business Media New York 1998 Colon.Vivo.cytokine.c

[復(fù)制鏈接]
查看: 25010|回復(fù): 66
樓主
發(fā)表于 2025-3-21 19:12:57 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Cytokine Knockouts
編輯Scott K. Durum,Kathrin Muegge
視頻videohttp://file.papertrans.cn/243/242629/242629.mp4
叢書名稱Contemporary Immunology
圖書封面Titlebook: Cytokine Knockouts;  Scott K. Durum,Kathrin Muegge Book 19981st edition Springer Science+Business Media New York 1998 Colon.Vivo.cytokine.c
描述My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func- tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al- though the latter finding is of course a wonderful incentive for fur- ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to be
出版日期Book 19981st edition
關(guān)鍵詞Colon; Vivo; cytokine; cytokines; development; enzyme; enzymes; genes; immunodeficiency; interferon; metabolis
版次1
doihttps://doi.org/10.1007/978-1-4757-2753-1
isbn_ebook978-1-4757-2753-1
copyrightSpringer Science+Business Media New York 1998
The information of publication is updating

書目名稱Cytokine Knockouts影響因子(影響力)




書目名稱Cytokine Knockouts影響因子(影響力)學(xué)科排名




書目名稱Cytokine Knockouts網(wǎng)絡(luò)公開度




書目名稱Cytokine Knockouts網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱Cytokine Knockouts被引頻次




書目名稱Cytokine Knockouts被引頻次學(xué)科排名




書目名稱Cytokine Knockouts年度引用




書目名稱Cytokine Knockouts年度引用學(xué)科排名




書目名稱Cytokine Knockouts讀者反饋




書目名稱Cytokine Knockouts讀者反饋學(xué)科排名




單選投票, 共有 1 人參與投票
 

0票 0.00%

Perfect with Aesthetics

 

0票 0.00%

Better Implies Difficulty

 

0票 0.00%

Good and Satisfactory

 

1票 100.00%

Adverse Performance

 

0票 0.00%

Disdainful Garbage

您所在的用戶組沒有投票權(quán)限
沙發(fā)
發(fā)表于 2025-3-21 22:28:46 | 只看該作者
板凳
發(fā)表于 2025-3-22 03:50:18 | 只看該作者
地板
發(fā)表于 2025-3-22 04:40:25 | 只看該作者
5#
發(fā)表于 2025-3-22 12:30:35 | 只看該作者
Russell L. Ciochon,Gregg F. Gunnells to TNF receptor-mediated effects tends to be obscured in single gene knockout mice, because the loss of one ligand may be compensated by the remaining one. Since both genes are very closely linked and map within the major histo compatibility complex (MHC), single mutations cannot be crossed togeth
6#
發(fā)表于 2025-3-22 16:04:45 | 只看該作者
7#
發(fā)表于 2025-3-22 17:49:19 | 只看該作者
https://doi.org/10.1057/978-1-137-54786-6, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) display overlapping activities with IL-6 that may be explained by a common receptor signal transducing component (gp 130). In order to clarify the unique functions of IL-6 in vivo, we have disrupted the murine IL-6 gene in the second exon b
8#
發(fā)表于 2025-3-23 00:20:44 | 只看該作者
https://doi.org/10.1007/978-3-030-26376-8e receptor complexes for IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1) .. The discovery of this shared signal transducer, gp 130, helps to explain how these different cytokines can mediate overlapping biological functions
9#
發(fā)表于 2025-3-23 03:25:05 | 只看該作者
10#
發(fā)表于 2025-3-23 06:59:20 | 只看該作者
The IL-2 Deficiency Syndrome,e excluded, and the different sources of the two lymphokines, i.e., mainly activated T-cells for IL-2 versus a wide variety of non-lymphocytic cells for IL-15 . predict that in vivo, the two cytokines will play quite distinct roles in the regulation of lymphocyte activation. Therefore, it will be im
 關(guān)于派博傳思  派博傳思旗下網(wǎng)站  友情鏈接
派博傳思介紹 公司地理位置 論文服務(wù)流程 影響因子官網(wǎng) 吾愛論文網(wǎng) 大講堂 北京大學(xué) Oxford Uni. Harvard Uni.
發(fā)展歷史沿革 期刊點(diǎn)評 投稿經(jīng)驗(yàn)總結(jié) SCIENCEGARD IMPACTFACTOR 派博系數(shù) 清華大學(xué) Yale Uni. Stanford Uni.
QQ|Archiver|手機(jī)版|小黑屋| 派博傳思國際 ( 京公網(wǎng)安備110108008328) GMT+8, 2025-10-16 23:02
Copyright © 2001-2015 派博傳思   京公網(wǎng)安備110108008328 版權(quán)所有 All rights reserved
快速回復(fù) 返回頂部 返回列表
宜兰市| 永宁县| 舒城县| 滨海县| 孝昌县| 武汉市| 绿春县| 忻城县| 鄂温| 营口市| 成都市| 保靖县| 海口市| 雷州市| 巴彦淖尔市| 蕲春县| 石门县| 铁岭市| 镇安县| 萍乡市| 伽师县| 八宿县| 南陵县| 横山县| 西林县| 克什克腾旗| 盐津县| 四子王旗| 东莞市| 绥德县| 富川| 晋江市| 新丰县| 广州市| 江安县| 竹北市| 聂拉木县| 定结县| 潮州市| 泰来县| 克东县|