Titlebook: Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium; Rudolf Toman,Robert A. Heinzen,Jean-Louis Me

athlete’s-foot

Johann Fuchs,Markus Hummel,Gerd Zikaand dairy sheep, improved hygiene measures, and culling of pregnant animals on infected farms. The introduction of these drastic veterinary measures has probably ended the Q fever outbreak, for which the Netherlands was ill-prepared.

indigenous

Phylogenetic Diversity, Virulence and Comparative Genomics, that there is much to learn about this unique intracellular pathogen, especially with the speculation of a hyper-virulent strain contributing to an outbreak in the Netherlands where over 4,000 human cases were reported. A new era in . research has begun with the recent description of an axenic medi

Conflagration

Defense Mechanisms Against Oxidative Stress in ,: Adaptation to a Unique Intracellular Niche, phagolysosome. Within the environment of the PV, . is exposed to varying levels of ROS and RNS, which represent the primary defense mechanism of the host cell against this invading microorganism. Major mediators for ROS and RNS are superoxide (O.) and nitric oxide (NO.), generated by the cellular N

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Components of Protective Immunity,ine against Q fever. This chapter describes new information related to the characterization of acquired immunity to . vaccination and infection that will provide a fundamental understanding of the development of protective immunity against Q fever.

Chauvinistic

, Subversion of Intracellular Host Signaling,tism. Collectively, recent signaling studies have enhanced our understanding of the unique .-host cell interaction. Identification of bacterial factors that regulate signaling events will further our ability to model this intriguing infectious process.

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珊瑚

Genetic Manipulation of ,,ium that supports host cell-free growth of the organism in liquid, and importantly, on solid media as clonal colonies. The expanded . genetics toolbox now includes transposon systems for random mutagenesis and single-copy, site-specific chromosomal gene knock-ins, as well as a shuttle vector for het

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