Titlebook: Copper-Catalyzed Multi-Component Reactions; Synthesis of Nitroge Yusuke Ohta Book 2011 Springer-Verlag Berlin Heidelberg 2011 atom economy.

Exclude

Identifying the needs of a target groupino three-component coupling-cyclization using an appropriate ethynylaniline, aldehyde, and a secondary amine, treatment with .-BuOK/hexane or MsOH afforded the desired tetrahydro-β-carboline derivatives in moderate to good yields.

indoctrinate

Identifying the needs of a target groupeloped. Treatment of 2-ethynylbenzaldehydes with paraformaldehyde, secondary amine, and .-BuNH. in the presence of a catalytic amount of CuI in DMF affords 3-(aminomethyl)isoquinolines in good yields, through successive formation of one carbon–carbon and three carbon–nitrogen bonds.

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Evaluating the outcomes of a group programmeon, has been developed. A Mannich-type reaction with 2-ethynylbenzaldehyde, paraformaldehyde, and a secondary amine followed by treatment with a diamine component gave tricyclic isoquinolines through cascade cyclization and oxidation. Construction of fused isoquinolines of various ring sizes is also presented.

innovation

Identifying the needs of a target groupures found in bioactive compounds, natural products, and so on. It is also important to effectively utilize the limited carbon resources minimizing the requisite reagents, solvents, cost, time, separation processes, and wastes [., .]. The multi-component reaction (MCR) [.–.], represented by Ugi’s fo

tenosynovitis

Identifying the needs of a target groupnnich-type reaction using 2-ethynylanilines, aldehydes, and secondary amines, followed by hydroamination. This is the first example of three-component indole formation without producing any salts as a byproduct. Using alkyl aldehydes and the chiral ligand PINAP, the corresponding indole bearing a br

Anticlimax

Eclampsia

Identifying the needs of a target groupino three-component coupling-cyclization using an appropriate ethynylaniline, aldehyde, and a secondary amine, treatment with .-BuOK/hexane or MsOH afforded the desired tetrahydro-β-carboline derivatives in moderate to good yields.

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Inelasticity

流動(dòng)性

Yusuke OhtaNominated by the University of Kyoto (Pharmaceutical Sciences), Japan for a Springer.The work of the thesis will inspire synthetic research of many readers..This research is the first example of a thr