| 書目名稱 | Copper-Catalyzed Multi-Component Reactions |
| 副標(biāo)題 | Synthesis of Nitroge |
| 編輯 | Yusuke Ohta |
| 視頻video | http://file.papertrans.cn/239/238179/238179.mp4 |
| 概述 | Nominated by the University of Kyoto (Pharmaceutical Sciences), Japan for a Springer.The work of the thesis will inspire synthetic research of many readers..This research is the first example of a thr |
| 叢書名稱 | Springer Theses |
| 圖書封面 |  |
| 描述 | A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure.This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers. |
| 出版日期 | Book 2011 |
| 關(guān)鍵詞 | atom economy; bioactive compounds; complex heterocyclic structures; copper salt; green chemistry; indole |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-15473-7 |
| isbn_softcover | 978-3-642-26701-7 |
| isbn_ebook | 978-3-642-15473-7Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer-Verlag Berlin Heidelberg 2011 |
|Archiver|手機(jī)版|小黑屋|
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