Titlebook: Comparative Genetic Toxicology; J. M. Parry,C. F. Arlett Book 1985 Palgrave Macmillan, a division of Macmillan Publishers Limited 1985 com

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書(shū)目名稱Comparative Genetic Toxicology影響因子(影響力)




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BAIT

UNT

Salmonella Mutagenicity Testing of Benzidine, 4,4″-Diaminoterphenyl, 4-Dimethylaminoazobenzene and 4t S9 was compared with DDT-induced rat and 3-methylcholanthrene (MC)-induced guinea pig S9, the latter producing the greatest numbers of revertants per microgram of BZD, DAT and CDA. DAB had the weakest mutagenic activity, demonstrable only with rat-Aroclor and guinea pig-MC S9. DAT was the only com

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Reverse Mutation in ,s analogue CDA, with both uninduced rat liver S9 and chicken liver S9. The test chemicals, S9 and bacterial cultures were provided by the study organisers, and we employed standard methods and experimental design as required. The results that we obtained are described below.

OREX

偽善

偽善

臨時(shí)抱佛腳

Callus

A Comparison of the Effects of Uninduced Mouse, Uninduced Rat and Aroclor-induced Rat Liver S9 on Reinduced mouse and uninduced rat liver S9. For the purpose of comparison we also included our own induced rat liver S9, prepared according to the method of Ames .. (1975) from Fischer 344 rats which had been treated with Aroclor 1254 at 500 mg/kg over a five day period.

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Mutagenicity of BZD, DAT, DAB and CDA in the Bacterial Mutagenicity Testd from Aroclor induced rat or uninduced mouse liver. The S9 fraction in the S9 mix was varied to give 4%, 10% or 30% concentration. Each compond was tested three times with similar results. Only DAT and BZD showed a positive mutagenic response. The magnitude of the response varied with the species,