Titlebook: Clinically Relevant Resistance in Cancer Chemotherapy; Borje Andersson,David Murray Book 2002 Springer Science+Business Media New York 200

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書目名稱Clinically Relevant Resistance in Cancer Chemotherapy影響因子(影響力)




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Bumptious

The Role of Membrane Transporters in Cellular Resistance to Anticancer Nucleoside Drugs, in lipid bilayers, and their cellular uptake is mediated by integral membrane proteins. Nucleoside transporters serve as the cellular entry point for nucleoside salvage pathways. Some cell types use these pathways exclusively because they lack the ability to synthesize purine and pyrimidine nucleot

degradation

Simulate

The Glutathione System in Alkylator Resistance, can be intrinsically resistant to chemotherapy or, in other cases, develop resistance during the course of antineoplastic treatment. This acquired resistance is thought to occur through the selection of a subpopulation of resistant tumor cells as the tumor is exposed to chemotherapy. To complicate

得意人

夸張

Mechanisms of Repair of Interstrand Crosslinks in DNA,d War, making these agents among the oldest, and yet still most effective, anticancer drugs available in the clinic. The alkylation chemistry of these drugs was elucidated shortly after the War, and their cellular pharmacology was studied extensively during the 1970s and 1980s.. In contemporary chem

夸張

DNA Repair in Resistance to Bifunctional Alkylating and Platinating Agents,eutic agents. This rationale naturally extends to understanding the properties of tumor cells that make them responsive versus resistant to anticancer drugs. Many factors can contribute to the drug-resistant phenotype of individual tumor cells, and indeed, clinically relevant resistance in a given t

characteristic

Leukemic Cell Insensitivity to Cyclophosphamide and other Oxazaphosphorines Mediated by Aldehyde Deeroxyifosfamide, on the part of the leukemias for which these agents are used is encountered all too often clinically. Increased detoxification of the oxazaphosphorines catalyzed by relatively elevated levels of any of several aldehyde dehydrogenases (ALDHs) present in target (malignant) cells could

不朽中國(guó)

Mechanisms of Resistance against Cyclophosphamide and Ifosfamide: Can they be Overcome without Sacrrst synthesized as an anticancer drug four decades ago, it continues to be widely used because of its unique efficacy against a broad range of human cancers.. To date, the structural isomer ifosfamide (IF, Ifos) is the most clinically useful CP analog, although its current applications in chemothera

淡紫色花

Cellular Mechanisms of Cyclophosphamide Resistance: Model Studies in Human Medulloblastoma Cell Linldren’. Phase 2 trials in children with recurrent and newly diagnosed medulloblastoma have confirmed both clinical and radiographic responses to this alkylating agent.and a current Children’s Oncology Group international Phase 3 trial is comparing a cyclophosphamide-based regimen to a CCNU-based reg