Titlebook: Chromosomal Aberrations; Basic and Applied As Günter Obe,A. T. Natarajan Book 1990 Springer-Verlag Berlin Heidelberg 1990 Chromosomen.DNA.D

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Restriction Endonuclease- and Radiation-Induced DNA Double-Strand Breaks and Chromosomal Aberrationbonds. In an irradiated cell, therefore, damage can occur at any point in the structure of DNA. As a result of this high energy per ionizing event, radiation is able to induce a variety of lesions in the DNA of cells which can be grouped into those involving damage to the base moeity without breakag

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Induction of Chromosomal Aberrations by the Restriction Endonuclease AluI in Chinese Hamster Ovary berrations is a DNA double-strand break (Obe et al. 1987; Bryant, this Vol.; Morgan et al., this Vol.). It is still not clear how living cells can uptake REs. Different methods have been used to treat cells with REs (for discussion see Bryant 1988; Morgan et al., this Vol.) and all of them are more

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Tumorigenesis and Tumor Response: View from the (Prematurely Condensed) Chromosome, breakage syndromes such as ataxia telangiectasia and xeroderma pigmentosum or constitutional chromosomal abnormalities are found to be at high risk for the development of malignancy (Lejeune et al. 1959; Ray and German 1981). Similarly, individuals who have increased exposure to clastogenic agents

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Detection of Cancer-Prone Individuals Using Cytogenetic Response to X-Rays,e, among others, ataxia telangiectasia, Bloom’s syndrome, familial polyposis, Fanconi’s anemia, Gardner’s syndrome, and xeroderma pigmentosum (Setlow 1978). We have shown that skin fibroblasts from affected individuals or individuals with a family history of cancer, compared to cells from clinically

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Possible Causes of Variability of the Adaptive Response in Human Lymphocytes,ubsequently, the emphasis was shifted to mutation as a cellular process in which the primary lesion was extensively modified by enzymatic DNA-repair systems constitutively present in the cell (Auerbach 1976). Finally, over the past 15 years, considerable interest has been focused on inducible cellul