Titlebook: Cholesterol; Its Functions and Me Robert Bittman Book 1997 Springer Science+Business Media New York 1997 Lipid.development.metabolism.nervo

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Cholesterol Deposition in Atherosclerotic Lesions,blood vessels leads to the development of atherosclerotic plaque-like lesions. Heart attacks and some types of strokes occur when these plaques rupture and blood clots form on their surfaces. In the United States, heart attacks and strokes kill more than 500,000 people each year (American Heart Asso

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Cholesterol Metabolism and Tumor Cell Proliferation,nes and bile salts to its less specifically understood but critical role as a principal lipid component of every cell membrane. Cholesterol biosynthesis begins with metabolically supplied cytoplasmic acetyl CoA that also serves as the common precursor for . fatty acid synthesis, and can be expressed

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Cholesterol Cytochemistry in Cell Biology and Disease,precisely where and in what amount cholesterol is present offers potentially useful insights into the functional role of this lipid as a constituent of normal membranes, and the part it plays in the pathogenesis of diseases that involve dysfunction of cholesterol homeostasis. The cholesterol content

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Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway, a, steroid hormones, 1,25-dihydroxy vitamin D, bile acids, and geranylgeranyl diphosphate (Figure 1). Isoprenoid moieties, such as farnesyl and geranylgeranyl, are also post-translationally attached to certain proteins to produce prenylated proteins (Figure 1). Such modifications affect the localiz

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Has Nature Designed the Cholesterol Side Chain for Optimal Interaction with Phospholipids?,e some recent kinetic studies of intermembrane movement and intracellular transport of sterols having a side-chain structure different from that of cholesterol. For a recent review of other aspects of sterol-phospholipid interactions, including a more detailed discussion of the use of NMR spectrosco