期刊全稱 | Biomedical Applications of Acridines | 期刊簡稱 | Derivatives, Synthes | 影響因子2023 | Jan Je?ek,Jan Hlavá?ek,Jaroslav ?ebestík | 視頻video | http://file.papertrans.cn/188/187989/187989.mp4 | 發(fā)行地址 | Describes modern and conventional syntheses of acridine scaffolds.Presents structural aspects of interactions with proteins which provide useful tips for designing enzyme inhibitors involved in the tr | 學(xué)科分類 | Progress in Drug Research | 圖書封面 |  | 影響因子 | .This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can ?be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.?. | Pindex | Book 2017 |
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