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Titlebook: Biomedical Applications of Acridines; Derivatives, Synthes Jan Je?ek,Jan Hlavá?ek,Jaroslav ?ebestík Book 2017 Springer International Publis

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發(fā)表于 2025-3-21 18:15:12 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Biomedical Applications of Acridines
期刊簡(jiǎn)稱Derivatives, Synthes
影響因子2023Jan Je?ek,Jan Hlavá?ek,Jaroslav ?ebestík
視頻videohttp://file.papertrans.cn/188/187989/187989.mp4
發(fā)行地址Describes modern and conventional syntheses of acridine scaffolds.Presents structural aspects of interactions with proteins which provide useful tips for designing enzyme inhibitors involved in the tr
學(xué)科分類Progress in Drug Research
圖書(shū)封面Titlebook: Biomedical Applications of Acridines; Derivatives, Synthes Jan Je?ek,Jan Hlavá?ek,Jaroslav ?ebestík Book 2017 Springer International Publis
影響因子.This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can ?be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.?.
Pindex Book 2017
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發(fā)表于 2025-3-21 20:31:51 | 只看該作者
Syntheses,d; however, overreactions are possible. Many building blocks for peptide synthesis bearing acridine unit are available. The synthesized peptide conjugates can serve as drugs, gene delivery systems, imaging agents, etc. Furthermore, acridines with chelating groups can be used as rigid ligands for org
板凳
發(fā)表于 2025-3-22 00:56:14 | 只看該作者
0071-786X employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.?.978-3-319-87680-1978-3-319-63953-6Series ISSN 0071-786X Series E-ISSN 2297-4555
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發(fā)表于 2025-3-22 09:52:56 | 只看該作者
Sowmiya Chandramoorthi,Arun K. Thittai, inflammation, immunological disorders, protozoal diseases, etc. General introduction to the field of acridines is provided including scope and limitations of the field. Some important structures, which are used as drugs, are highlighted.
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發(fā)表于 2025-3-22 23:05:51 | 只看該作者
Some Application of Selective Toxicities of Acridines, combating HIV. Moreover, interactions with immune system can overcome failure of human immune system suppressing either cancer or massive autoimmune response. In this chapter, we briefly describe the role of acridines in fight with tropical diseases, cancer, and bacterial infections.
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發(fā)表于 2025-3-23 04:45:37 | 只看該作者
Signals and Communication Technologyonjugates with anti-oxidants, metal chelators, or anion binders are constructed. Moreover, the reader can see how subtle alterations of acridine structure can serve for detection of prion strains i.e. most probably various conformations of pathogenic proteins.
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發(fā)表于 2025-3-23 09:13:23 | 只看該作者
Signals and Communication Technologynsoluble acridones can also appear. In tumor cells, the reductive environment can provide partially hydrogenated acridines. Rapid metabolism of some acridines can lead to failure of the drugs in clinical trials.
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