Titlebook: Biology of Cellular Transducing Signals; Jack Y. Vanderhoek Book 1990 Plenum Press, New York 1990 Calcium.Colon.DNA.Nucleotide.cyclin.enzy

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Antibodies as Probes of G-Protein Structure and Function tubulin, soluble proteins (initiation and elongation factors involved in protein synthesis), and low molecular weight GTP-binding proteins such as the . p21 protooncogenes and .-related proteins (Spiegel, 1987; Gilman, 1987; Iyengar & Birnbaumer, 1987). Members of the G-protein subset of the GTP-bi

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‘Cross-Talk’ and the Regulation of Repatocyte Adenylate Cyclase Activity: Desensitization, G1 and Cyacellular concentrations of cyclic AMP. In hepatocytes, glucagon achieves just this (fig.1). We show that such an event is determined by the initial rapid activation of adenylate cyclase which is then followed by the activation of a specific cyclic AMP phosphodiesterase and desensitization of adenyl

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Cytoskeletal Participation in the Signal Transduction Process: Tubulin G Protein Interactions in the discovered as proteins which conferred stimulation [Gs] or inhibition [Gi] upon adenylate cyclase. Since their initial discovery, these proteins have been assigned new roles at an alarming rate. Further, molecular genetic techniques have demonstrated that the signal transducing G proteins [for this

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Initiation and Modulation of Signal Output from the T cell Antigen Receptorx molecules. The T cell receptor for antigen is a multimeric structure consisting of a polymorphic, antigen-binding heterodimer (T.) noncovalently associated with a series of at least 5 invariant polypeptides termed CD3 (Samelson et al., 1985; Baniyash et al., 1988). The highly polymorphic nature of

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