Titlebook: Biochemistry and Cell Biology of Ageing: Part I Biomedical Science; J. Robin Harris,Viktor I. Korolchuk Book 2018 Springer Nature Singapor

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Springer Nature Singapore Pte Ltd. 2018

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https://doi.org/10.1007/978-0-387-71718-0he accumulation of damaged proteins and organelles which, in turn, can cause cellular toxicity and death. Autophagy is an evolutionarily conserved process that is responsible for the sequestration of damaged or surplus cytoplasmic components which are then delivered to the lysosome for degradation.

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https://doi.org/10.1007/978-0-387-71718-0ical or dietary interventions targeting nutrient signaling pathways have been shown to robustly attenuate ageing in many organisms. Caloric restriction, the most widely studied longevity promoting intervention, works through multiple nutrient signaling pathways, while inhibition of mTOR through trea

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