Titlebook: Biochemistry and Cell Biology of Ageing: Part I Biomedical Science; J. Robin Harris,Viktor I. Korolchuk Book 2018 Springer Nature Singapor

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肥料

,Autophagy: ‘Self-Eating’ Your Way to Longevity,he accumulation of damaged proteins and organelles which, in turn, can cause cellular toxicity and death. Autophagy is an evolutionarily conserved process that is responsible for the sequestration of damaged or surplus cytoplasmic components which are then delivered to the lysosome for degradation.

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Extracellular Matrix and Ageing,ral support, influences many important cell process within the body. As a result, age-related changes to the proteins of the ECM have far reaching consequences with the potential to disrupt many different aspects of homeostasis and healthy function. The proteins collagen and elastin are the most abu

Harness

Vitamin D and Ageing,n our knowledge of vitamin D has expanded tremendously and has included recognition of the importance of UV radiation as a source of the vitamin as well as the discovery of the vitamin as a nutrient, a pro-hormone and a potent steroid hormone with a major role in calcium and bone metabolism. In the

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Telomeres, Telomerase and Ageing,s a protein complex called shelterin. Together, they form a protective loop structure against chromosome fusion and degradation. Shortening or damage to telomeres and opening of the loop induce an uncapped state that triggers a DNA damage response resulting in senescence or apoptosis..Average telome

生來(lái)

Nuclear DNA Damage and Ageing,ks between genome maintenance pathways, lifespan regulation mechanisms and age-related diseases in mammals. Indeed, the growing number of DNA repair-deficient patients with progeria suggests that persistent DNA damage and genome caretakers are tightly linked to lifespan regulating circuits and age-r