Titlebook: Biochemical Basis and Therapeutic Implications of Angiogenesis; Jawahar L. Mehta,Pankaj Mathur,Naranjan S. Dhalla Book 2017Latest edition

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Role of Transforming Growth Factor Beta Family in Angiogenesisable for development and homeostasis of the vascular system. TGFβ drives vascular responses via its binding to a TGFβ receptor complex formed by type I and type II receptors, as well a type III co-receptors present on both endothelial and mural cells. Signaling by these receptors is context dependen

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Angiogenesis-Based Strategy by Hepatocyte Growth Factor for the Treatment of Ischemic Organ Diseases activities in epithelial cells through tyrosine phosphorylation of its receptor, c-Met. HGF-c-Met axis is necessary for embryogenesis, organogenesis and tissue repair of almost epithelial organs. Indeed, a loss in HGF-c-Met signaling pathways leads to organ damage and dysfunction during acute and c

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Mast Cells in Angiogenesis: The Role of Angiogenic Cytokinesin this process is mostly certain related to the release of a large spectrum of angiogenic cytokines, including vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), transforming growth factor beta (TGFβ), tumor necrosis factor alpha (TNFα), interleukin-8 (IL-8) and angiopoi

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Therapeutic Implications of Angiogenesis in Cancero become cancer-disease without activating angiogenesis. This chapter addresses the factors involved in tumor angiogenesis and the progress made to exploit this phenomenon. Tumors are very heterogeneous in their angiogenic pathways and drugs targeting angiogenesis are moderately effective in the met

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Angiogenesis and Prostate Cancer: Friends or Foes) that can help investigators to design specific anti-angiogenic strategies, it is reasonable to assume that the quantification of various aspects of tumor vasculature may provide an indication of angiogenic activity. It has been ascertained that malignant tumors can generate their vasculature in se

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