Titlebook: Behavioral Neuroscience of Orexin/Hypocretin; Andrew J Lawrence,Luis de Lecea Book 2017 Springer International Publishing AG 2017 orexin/h

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Sharing Documents with Share Buttons,umulation is the main hallmark of AD pathology, while tau proteins mark brain neuronal injury due to AD pathology. Investigations so far suggest that orexinergic signaling overexpression alters the sleep–wake cycle and secondarily induces beta-amyloid accumulation and tau-mediated neurodegeneration.

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1866-3370 advanced clinical trials are currently underway for orexin receptor antagonists in the treatment of insomnia and sleep disorders. We aim to capture a broad audience of basic scientists and clinicians..978-3-319-86187-6978-3-319-57535-3Series ISSN 1866-3370 Series E-ISSN 1866-3389

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https://doi.org/10.1057/9780230597860retin neuropeptides. Orexins/hypocretins produced by neurons in the lateral hypothalamus stimulate their cognate GPCRs in multiple regions of the central nervous system to control sleep and arousal, circadian rhythms, metabolism, reward pathways, and other behaviors. Dysfunction of orexin/hypocretin

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The Role of Auditing in an OrganizationX. orexin receptors, as described in the previous chapters. Signaling of orexin peptides has been investigated in diverse endogenously orexin receptor-expressing cells – mainly neurons but also other types of cells – and in recombinant cells expressing the receptors in a heterologous manner. Finding

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What is Meant by ‘Internal Control’?ustness via redundancy’, wherein wakefulness control is not critically dependent on one type of neuron or molecule. Studies of the brain orexin/hypocretin system challenge this view by demonstrating that wakefulness control fails upon loss of this neurotransmitter system. Since orexin neurons signal

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Developmental Dimensions of Innovationroject widely throughout the brain and the physiologic and behavioral functions of OX are much more complex than initially conceived based upon the stimulation of feeding. OX most notably controls functions relevant to attention, alertness, and motivation. OX also plays multiple crucial roles in the